The three car crash took place on the N25 from Youghal to Killeagh in Burgess at about 4.30p.m
The cars collided at the junction of a filling station on the road.
Three people were taken to Cork University Hospital, however the elderly woman later died on Sunday. The others, a 46 year old man and a 27 year old woman have since been discharged from hospital.
Gardaí are appealing for anyone travelling on the road at Burgess between 4pm and 4:30pm on Friday, or anyone who witnessed the crash to contact them at Midleton Garda Station on 021 462 1550