The body of the French filmmaker was found outside her holiday home in Toormore near Schull in December 1996
The Irish Independent reports that Detective Inspector Eamon Brady's full involvement in the investigation come as a new focus on DNA gets underway which is expected to focus on preserved exhibits.
Scientific advances mean it may now be possible to identify tiny particles of genetic information separate from Ms Toscan du Plantier's own tissue.
Work by Detective Inspector Brady along with a team of officers in the 1981 murder of Nora Sheehan led to the recent life imprisonment of Noel Long