The incident happened shortly after 11am this morning
It happened close to the Oven's Bar at the end of the N22 bypass.
3 units of the fire service from Ballincollig and Anglesea Street, as well as Gardai and the national Ambulance Service responded.
The driver of the car, a man aged in his 40s, was pronounced dead at the scene when the car he was travelling in collided with a lorry.
No one else was injured in the crash.
Gardai remain at the scene as Forensic Collision Investigators examine the scene.
Anyone with information is asked to contact Gurranabraher Garda Station on 021 4946200, the Garda Confidential Line 1800 666 111 or any Garda Station.
