Heroin, Xanax tablets, ecstasy and cocaine were discovered on Thursday
It follows two separate Garda operations at a house and industrial premises in the City Centre.
Two men, in their 30s and 40s, were arrested.
The man in his 30s has been charged and is due before the courts this morning.
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In a separate incident, Gardaí in Mallow investigating the drug seizure that occurred on Thursday evening on the Mitchelstown Road in Mallow have charged the second man that was arrested.
The man in his late 40s was charged late last night and is due to appear before a special sitting of Mallow District Court, at 12 noon today.
It's understood a car failed to stop at a checkpoint and a man received non-life threatening injuries to the shoulder.
During follow-up searches around 20,000 euro in cash and drugs were discovered.