The airline already operates services from Cork Airport to Milan/Bergamo and Venice/Marco Polo.
It brings to 27 the number of Ryanair routes available from Cork this winter.
Cork Airport have welcomed the launch as a welcome boost to tourism in Cork and across the south of Ireland.
Head of Visit Cork, Seamus Heaney welcomed the enhanced connectivity:
"As an island, Ireland needs good air connectivity for the movement of both people and trade. The connectivity between Cork, Milan, Rome and Venice is a positive move for the region as it opens up great possibilities for Italian visitors to explore Cork and the South of Ireland."
