The extra measures came into place for Donegal last night
Dr Ronan Glynn has urged people there and in Dublin to pay special attention to the public health advice.
326 new cases of coronavirus were confirmed yesterday evening and no further deaths.
152 are in Dublin, 32 in Cork, 22 in Donegal, 21 in Galway, 15 in Meath and 11 in Kildare - with the rest spread across 15 other counties.