Clerical and administrative staff in the HSE are to begin industrial action.
93.3% of members of Fórsa, working in those roles, backed the move.
The union says the ballot was prompted by the HSE’s decision in July to halt all recruitment of clerical and administrative staff.
It claims the HSE is increasingly relying on agency staff and spending 'extravagant' amounts on external private consultants - instead of investing in upskilling, training or promoting the existing workforce.
Industrial action will begin in early September - in the form of non-cooperation with some aspects of their work, as well as no voluntary working outside of contracted hours.
The union's mandate includes an option for full strike action if members feel it's necessary.