2.6 million properties are without power and thousands of people are sheltering in schools and community centres.
Winds of 150 miles per hour have battered the state, and some beach resorts are completely under water.
Joe Biden's promising to visit the area soon, and sent this message:
"We're gonna learn a lot more in the coming hours, but we know many families are hurting. Many, many are hurting today, and our entire country hurts with them. Because it's been all over the country we've have seen so many crises, but in Florida today is the epicentre."
