Gardai are appealing for witnesses to both crashes.
At around 10 o'clock last night a pedestrian was hit by a car on the N25 at Portersland near New Ross in Wexford
The 36 year old man was taken to University Hospital Waterford but later died - the driver of the car was uninjured.
In Donegal, 19 year old man was killed and three men have been injured in a two car crash on the N56 at Creeslough.
It happened at around 9:30pm last night.