Cork's Hotels and B&Bs are welcoming back guests for the first time in more than 5 months today.
Guesthouses and self-catering accommodation can also reopen, as part of the government's planned easing of restrictions.
The Irish Hotels Federation says today's reopening will result in more than 30,000 staff returning to work over the summer.
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The Port of Cork is to fence off sections of it's quays ahead of the bank holiday to prevent large crowds from gathering.
Gardai had to clear people socilaising from the quays over the weekend after hundreds gathered.
There were 12 arrests for public order offences in the city on the Saturday.
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The HSE's registration system for a Covid-19 vaccine opens today for people aged 40 to 44.
44-year-olds can sign up online or by phone today and 43-year-olds tomorrow.
The health service says it expects appointments will be scheduled from the middle of this month.
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The chief medical officer says the country will remain 'vulnerable' in June and July because a large amount of the population won't be vaccinated.
Dr Tony Holohan says no assurances can be given that the level of Covid-19 will remain similar to recent weeks.
In a letter to the Health Minister, he expressed concern about variants, particularly the Indian strain.