An all Munster half back pairing of Conor Murray and Joey Carbery will take to the field against Argentina on Sunday.
Andy Farrell's side aim to make it 3 wins from 3 in their Autumn Series after last weekends victory over the All Blacks
James Ryan assumes the captaincy in the absence of Johnny Sexton and is partnered in second row by Iain Henderson. The front row of Andrew Porter, Ronan Kelleher and Tadgh Furlong is retained as is the backrow of Caelan Doris, Josh van der Flier and Jack Conan.
Robbie Henshaw makes his season debut at inside centre partnering Garry Ringrose in the midfield.
Hugo Keenan gets another opportunity to impress in the No.15 jersey with James
Lowe starting his third consecutive game for Ireland. Robert Baloucoune who made his Ireland debut against the USA in July scoring a scintillating try gets his second start.