That's according to the Irish Small and Medium Enterprises Association
The Italian clash was the last of three home games in this year's tournament, with each worth millions to the Irish economy.
The IRFU says it will immediately begin to work with its Six Nations partners to look at the possibility of rescheduling the fixture.
Neil McDonnell, Chief Executive of ISME, says the decision to call off the game will have a negative economic impact on a huge number of businesses:
