'The Kelly Clarkson Show' will take the place of the major TV spot.
The Ellen DeGeneres Show is airing its nineteenth and final season this year, as announced earlier this month.
DeGeneres, 63, revealed she was stepping down earlier this month and said she was driven by ''instinct''.
The host said she had known she would walk away after 19 seasons when she signed her most recent deal two years ago.
DeGeneres dismissed claims she was quitting due to the toxic workplace allegations.
Senior producers on the show were sacked last year and DeGeneres apologised to her staff after an internal review by Warner Bros found "deficiencies related to the show’s day-to-day management".
It is now looking like 'The Kelly Clarkson Show' will be replacing the popular show.
Clarkson's talk show will take over the slot on NBC-owned stations from autumn 2022.
NBC said The Kelly Clarkson Show – now in its second season – will replace DeGeneres’ programme from autumn 2022.
The singer's talk show is currently in its second season. It got the green light late last year for two more seasons bringing it through to 2023.
Clarkson’s programme is owned and produced by NBC’s syndication arm.
Tracie Wilson, executive vice president, NBC Universal Syndication Studios, said: "Kelly and our entire production team put their heart, intent, and incredible passion into making a show that resonates with people of all ages, cultures, and backgrounds.
"We’re working on some big plans for season three and are looking forward to becoming the premier show in daytime for years to come."