The incident happened near Clones in Monaghan.
The collision which happened on 31st of July this year, resulted in the deaths of 17-year-old Kiea McCann and 16-year-old Dlava Mohamed.
The teenagers, and best friends were on their way to the Largy College school debs when the vehicle they were travelling in, hit a tree on a section of the N54 at Legnakelly near Clones in County Monaghan.
This morning, two men - aged in their 60s and 40s were arrested as part of the Garda investigation.
They're being detained at a Garda Station in County Monaghan.
Gardaí say investigations are ongoing, and further updates are expected to follow.